{"product_id":"pancreagen-peptide","title":"Pancreagen Peptide","description":"\u003cdiv class=\"ds-virtual-list-items _6f2c522\"\u003e\n\u003cdiv class=\"ds-virtual-list-visible-items\"\u003e\n\u003cdiv class=\"_4f9bf79 d7dc56a8 _43c05b5\"\u003e\n\u003cdiv class=\"ds-message _63c77b1\"\u003e\n\u003cdiv class=\"ds-markdown ds-assistant-message-main-content\"\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003e\u003ca href=\"https:\/\/corepeptides.in\/\"\u003eCorePeptides India\u003c\/a\u003e ships Pancreagen Peptide at 20 mg per vial-a sterile, lyophilized powder sealed under dry nitrogen. Every batch ships with a printed, mass‑confirmed Certificate of Analysis. The lot number on your vial ties directly to that document. No exceptions.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cspan class=\"\"\u003eProduct Specifications\u003c\/span\u003e\u003c\/h3\u003e\n\u003cdiv class=\"ds-scroll-area ds-scroll-area--show-on-focus-within ds-scroll-area--enabled _1210dd7 c03cafe9\"\u003e\n\u003ctable\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003e\u003cspan class=\"\"\u003eSpecification\u003c\/span\u003e\u003c\/th\u003e\n\u003cth\u003e\u003cspan class=\"\"\u003eDetail\u003c\/span\u003e\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan class=\"\"\u003eProduct Class \/ Category\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan class=\"\"\u003ePancreatic Exocrine Secretagogue Research Peptide\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan class=\"\"\u003eResearch Identifier\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan class=\"\"\u003eSynthetic CCK‑8 Analog Fragment; CorePeptides Catalog ID CPP‑PANC‑20\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan class=\"\"\u003eSupplier \/ Brand\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan class=\"\"\u003eCorePeptides India\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan class=\"\"\u003eHPLC Purity Threshold\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan class=\"\"\u003e\u0026gt;99% (RP‑HPLC, C18, 214 nm, batch‑specific)\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan class=\"\"\u003eTarget Receptors \/ Chemical Pathways\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan class=\"\"\u003eCholecystokinin A receptor (CCK1R)- potent in‑vitro agonism in isolated pancreatic acinar cell models; triggers intracellular Ca²⁺ mobilisation and zymogen granule exocytosis via phospholipase C‑β signalling\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan class=\"\"\u003eRegulatory Status\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan class=\"\"\u003eFor In‑Vitro \u0026amp; Laboratory Analytical Research Only. Not for human, veterinary, diagnostic, or therapeutic use.\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003chr\u003e\n\u003ch2\u003e\u003cspan class=\"\"\u003eResearch Overview \u0026amp; Mechanism of Action\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003ePancreagen Peptide is a synthetic sulfated octapeptide modelled on the highly conserved C‑terminal tetrapeptide motif of endogenous cholecystokinin. The sequence - Asp‑Tyr(SO₃H)‑Met‑Gly‑Trp‑Met‑Asp‑Phe‑NH₂ - carries a sulfated tyrosine at position 2. That sulfation is non‑negotiable for CCK1R affinity. In our laboratory, desulfated by‑product routinely elutes as a separate peak; our \u0026gt;99% threshold means that peak is undetectable in the final batch. The monoisotopic mass is 1143.3 Da. A 20 mg vial gives enough material for extensive concentration‑response profiling without unnecessary vial‑to‑vial variability.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eAt the bench, this peptide binds the CCK1 receptor on pancreatic acinar cells with sub‑nanomolar potency in albumin‑free buffer. Binding triggers Gαq‑mediated phospholipase C‑β activation, a rapid IP3‑dependent calcium spike, and apical amylase secretion that can be quantified directly in supernatant media. Researchers employ Pancreagen Peptide to dissect stimulus‑secretion coupling, map receptor internalisation kinetics, and model pancreatitis‑associated signalling in primary acinar cultures. Molar ratio matters sharply - if you’re running dose‑response curves in serum‑containing media, account for albumin binding shifting the apparent EC50. The lyophilized cake, especially at 20 mg fill weight, may show visible cracks or slight collapse. That’s an artefact of large‑mass freeze‑drying. Purity is verified by liquid chromatography and mass spectrometry, not cake appearance.\u003c\/span\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003e\u003cspan class=\"\"\u003eHandling, Reconstitution \u0026amp; Storage Protocol\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eStore the lyophilized vial at –20 °C. Short‑term ambient shipping - under 5 days - has no measurable effect on purity in our stability programme. Before opening, let the vial sit at room temperature for a full 20 minutes. A 20 mg cake holds more thermal mass than a 5 mg vial; rushing this step invites condensation and potential aggregation of the sulfated peptide.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eReconstitution for analytical research:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eUse sterile, degassed phosphate‑buffered saline (PBS, pH 7.4) or sterile bacteriostatic water.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eFor a stock analytical concentration of 1 mg\/mL, add 20 mL of diluent. Inject slowly against the inner glass wall and swirl gently. Do not vortex. The sulfated tyrosine makes the peptide slightly amphiphilic - mechanical foaming increases oxidation and adsorptive loss.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eThe 20 mg quantity suits large‑volume working stocks. If you require nanomolar to low‑micromolar concentrations for cell‑based assays, pre‑block pipette tips and microcentrifuge tubes with a 0.01% BSA solution for 10 minutes before use. Include 0.05–0.1% BSA directly in the assay buffer to maintain free‑peptide molar ratio during extended incubation.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eOnce reconstituted, store the solution at 2–8 °C and use within 2‑3 weeks. Single‑use aliquots are mandatory. Each freeze‑thaw cycle can reduce detectable amylase‑release signal by roughly 12‑18%, based on our internal QC data. Aliquoting by experiment removes that variable.\u003c\/span\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003e\u003cspan class=\"\"\u003eScientific References \u0026amp; External Citations\u003c\/span\u003e\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli class=\"ds-markdown-paragraph\"\u003e\n\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=cholecystokinin+acinar+cell+amylase+secretion\" rel=\"noreferrer\" target=\"_blank\"\u003e\u003cspan class=\"\"\u003ePubMed: Cholecystokinin Receptor \u0026amp; Acinar Cell Signalling\u003c\/span\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e\u003cspan\u003e -\u003c\/span\u003e Peer‑reviewed in‑vitro studies mapping CCK‑stimulated exocrine secretion, calcium dynamics, and receptor pharmacology.\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli class=\"ds-markdown-paragraph\"\u003e\n\u003ca href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/substance\/?term=CCK-8+sulfated\" rel=\"noreferrer\" target=\"_blank\"\u003e\u003cspan class=\"\"\u003ePubChem Compound: CCK‑8 (Sulfated)\u003c\/span\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e\u003cspan\u003e -\u003c\/span\u003e Structural identifiers, molecular mass, and chemical classification of the native CCK octapeptide motif.\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli class=\"ds-markdown-paragraph\"\u003e\n\u003ca href=\"https:\/\/clinicaltrials.gov\/search?term=pancreatic+exocrine+peptide\" rel=\"noreferrer\" target=\"_blank\"\u003e\u003cspan class=\"\"\u003eClinicalTrials.gov: Pancreatic Function Protocols\u003c\/span\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e\u003cspan\u003e -\u003c\/span\u003e Registered research protocols exploring exocrine pancreatic function and peptide stimulation in controlled settings.\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch2\u003e\u003cspan class=\"\"\u003eFrequently Asked Research Questions\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eWhat is the exact sequence and molecular weight of Pancreagen Peptide?\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan class=\"\"\u003eCorePeptides India supplies Pancreagen Peptide as the sulfated octapeptide with the sequence Asp‑Tyr(SO₃H)‑Met‑Gly‑Trp‑Met‑Asp‑Phe‑NH₂. The monoisotopic mass is 1143.3 Da. Sulfation of the tyrosine at position 2 is confirmed by ESI‑MS on every batch‑specific Certificate of Analysis.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eHow should I reconstitute the 20 mg vial for acinar cell secretion experiments?\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan class=\"\"\u003eAdd 20 mL of sterile PBS, pH 7.4, to achieve a 1 mg\/mL stock. Let the vial warm to room temperature first. Swirl gently - vortexing damages the sulfated peptide. For working concentrations below 10 µM, include 0.05–0.1% BSA in the assay buffer and pre‑block plasticware to minimise adsorptive loss.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eIs a batch‑matched Certificate of Analysis provided by CorePeptides India?\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan class=\"\"\u003eYes. Every 20 mg vial ships with a printed and digitally archived COA showing the RP‑HPLC purity, retention time, ESI‑MS spectrum, and observed mass. The lot number on the vial matches that COA one‑to‑one.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eCan Pancreagen Peptide be used in human clinical or diagnostic research?\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan class=\"\"\u003eNo. This peptide is manufactured exclusively for in‑vitro laboratory research. It is not authorised for human or veterinary administration, diagnostic procedures, or therapeutic development. All purchase orders are screened to enforce this restriction.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Core Supplements","offers":[{"title":"Default Title","offer_id":44198427951163,"sku":null,"price":5999.0,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0696\/6411\/2699\/files\/ChatGPTImageJul22_2026_12_42_14PM.png?v=1789453671","url":"https:\/\/peptidesinindia.org\/products\/pancreagen-peptide","provider":"Buy Peptides In India","version":"1.0","type":"link"}