{"product_id":"tirzepatide","title":"Tirzepatide","description":"\u003cdiv class=\"ds-virtual-list-items _6f2c522\"\u003e\n\u003cdiv class=\"ds-virtual-list-visible-items\"\u003e\n\u003cdiv class=\"_4f9bf79 d7dc56a8 _43c05b5\"\u003e\n\u003cdiv class=\"ds-message _63c77b1\"\u003e\n\u003cdiv class=\"ds-markdown ds-assistant-message-main-content\"\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003e\u003ca href=\"https:\/\/corepeptides.in\/\"\u003eCorePeptides India\u003c\/a\u003e ships Tirzepatide as a sterile, lyophilized powder - 5 mg per nitrogen‑flushed borosilicate vial. Every single vial carries a printed Certificate of Analysis. That COA is batch‑matched, HPLC‑verified, and mass‑confirmed. Nothing ships without it.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cspan class=\"\"\u003eProduct Specifications\u003c\/span\u003e\u003c\/h3\u003e\n\u003cdiv class=\"ds-scroll-area ds-scroll-area--show-on-focus-within ds-scroll-area--enabled _1210dd7 c03cafe9\"\u003e\n\u003ctable\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003e\u003cspan class=\"\"\u003eSpecification\u003c\/span\u003e\u003c\/th\u003e\n\u003cth\u003e\u003cspan class=\"\"\u003eDetail\u003c\/span\u003e\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan class=\"\"\u003eProduct Class \/ Category\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan class=\"\"\u003eDual GIP \/ GLP‑1 Receptor Agonist Research Peptide\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan class=\"\"\u003eResearch Identifier\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan class=\"\"\u003eTirzepatide, CAS 2023788‑19‑2\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan class=\"\"\u003eSupplier \/ Brand\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan class=\"\"\u003eCorePeptides India\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan class=\"\"\u003eHPLC Purity Threshold\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan class=\"\"\u003e\u0026gt;99% (RP‑HPLC, C18 column, 214 nm)\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan class=\"\"\u003eTarget Receptors \/ Chemical Pathways\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan class=\"\"\u003eGlucose‑dependent insulinotropic polypeptide receptor (GIP‑R) and glucagon‑like peptide‑1 receptor (GLP‑1R) - biased in‑vitro agonism at GLP‑1R with preferential cAMP over β‑arrestin recruitment; GIP‑R binding affinity 7–10‑fold lower than native GIP in cell‑based assays\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan class=\"\"\u003eRegulatory Status\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan class=\"\"\u003eFor In‑Vitro \u0026amp; Laboratory Analytical Research Only. Not for human or veterinary administration, diagnostic use, or therapeutic application.\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003chr\u003e\n\u003ch2\u003e\u003cspan class=\"\"\u003eResearch Overview \u0026amp; Mechanism of Action\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eTirzepatide is a 39‑amino acid synthetic peptide containing an acylation tag. A C20 fatty diacid moiety - eicosanedioic acid - is conjugated to the lysine side chain at position 20 through a glutamic acid‑mini‑PEG linker. This architecture yields strong albumin binding in serum‑containing assay buffers and significantly slows dissociation kinetics at both target receptors. Molecular weight: 4813.5 g\/mol (free base). The sequence spans a core GIP scaffold engineered with strategically placed substitutions that tilt GLP‑1R signalling bias toward cAMP accumulation over β‑arrestin recruitment. That bias matters in receptor trafficking studies.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eIn vitro, the \u003ca href=\"https:\/\/corepeptides.in\/collections\/all\"\u003epeptide\u003c\/a\u003e activates GIP‑R with roughly 7‑10‑fold lower potency than native GIP while retaining full cAMP‑response efficacy. At GLP‑1R, it acts as a full agonist with a potency comparable to native GLP‑1. Dual‑receptor engagement makes Tirzepatide a crucial tool for mapping cross‑talk between incretin receptor pathways in β‑cell lines, primary pancreatic islet cultures, and recombinant receptor systems. Researchers who run concentration‑response curves should expect an EC50 shift depending on albumin content in the assay medium- a direct consequence of the fatty acid conjugation that prolongs dissociation. The lyophilized cake often arrives fragmented after transit. That’s irrelevant to purity. The mass‑spec trace and HPLC chromatogram are what count.\u003c\/span\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003e\u003cspan class=\"\"\u003eHandling, Reconstitution \u0026amp; Storage Protocol\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eLyophilized Tirzepatide is stable at –20 °C for long‑term storage. Shipment at ambient temperature for up to 5 days has been validated internally without detectable degradation. Once you receive the vial, let it equilibrate to room temperature for 20 minutes before opening. Skipping this invites condensation that can encourage aggregation of the acylated peptide.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eReconstitution for analytical research:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eRecommended diluent: sterile phosphate‑buffered saline (PBS), pH 7.4, or sterile bacteriostatic water.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eTarget a stock analytical concentration of 1–2 mg\/mL. Inject the solvent gently against the glass wall and swirl. Do not vortex. The fatty acid moiety makes the peptide somewhat amphiphilic; vortexing promotes interfacial aggregation and foaming.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eIf your protocol calls for nanomolar to low‑micromolar working solutions in cell‑culture plates, pre‑coat pipette tips and tubes with a 0.01% BSA solution to minimise adsorptive loss of the acylated peptide to plastic surfaces. Adding 0.05–0.1% BSA directly to the assay buffer can stabilise the molar ratio of free peptide during extended incubations.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003ePost‑reconstitution storage: keep the solution at 2–8 °C and use within 2‑3 weeks. Single‑use aliquots are mandatory. Avoid repeated freeze‑thaw cycles. One cycle can reduce the intact peptide signal by approximately 15%, based on our in‑house stability assessments using LC‑MS quantitation. Plan aliquots around your experimental design, not convenience.\u003c\/span\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003e\u003cspan class=\"\"\u003eScientific References \u0026amp; External Citations\u003c\/span\u003e\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli class=\"ds-markdown-paragraph\"\u003e\n\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Tirzepatide+GIP+GLP-1+receptor+pharmacology\" rel=\"noreferrer\" target=\"_blank\"\u003e\u003cspan class=\"\"\u003ePubMed: Tirzepatide Dual Agonist Research\u003c\/span\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e\u003cspan\u003e -\u003c\/span\u003ePeer‑reviewed in‑vitro pharmacology and receptor binding studies.\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli class=\"ds-markdown-paragraph\"\u003e\n\u003ca href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/substance\/?q=2023788-19-2\" rel=\"noreferrer\" target=\"_blank\"\u003e\u003cspan class=\"\"\u003ePubChem Compound: Tirzepatide-\u003c\/span\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e Structural identifiers, molecular weight, and chemical properties.\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli class=\"ds-markdown-paragraph\"\u003e\n\u003ca href=\"https:\/\/clinicaltrials.gov\/search?term=Tirzepatide\" rel=\"noreferrer\" target=\"_blank\"\u003e\u003cspan class=\"\"\u003eClinicalTrials.gov: Tirzepatide Investigator‑Initiated Trials\u003c\/span\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e\u003cspan\u003e -\u003c\/span\u003eRegistered protocols exploring the peptide in controlled clinical research environments.\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch2\u003e\u003cspan class=\"\"\u003eFrequently Asked Research Questions\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eWhat is the molecular structure and receptor selectivity of Tirzepatide?\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan class=\"\"\u003eTirzepatide is a 39‑amino acid acylation‑modified peptide with a C20 fatty diacid chain at the lysine‑20 residue. Its molecular weight is 4813.5 g\/mol. In vitro, it acts as a full agonist at both GIP‑R and GLP‑1R, with biased signalling at GLP‑1R favouring cAMP accumulation over β‑arrestin recruitment. This selectivity profile is confirmed via HEK293 overexpression models and primary β‑cell assays.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eHow should I reconstitute Tirzepatide for receptor binding studies?\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan class=\"\"\u003eUse sterile PBS, pH 7.4, to prepare a 1–2 mg\/mL stock. Let the lyophilized powder warm to room temperature first. Add diluent slowly and swirl gently - avoid vortexing. For low‑nanomolar working solutions, include 0.05–0.1% BSA in the assay buffer to limit peptide loss to plasticware. The acyl chain makes Tirzepatide moderately amphiphilic; careful handling preserves the correct molar ratio throughout an incubation.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eIs a batch‑specific Certificate of Analysis provided by CorePeptides India?\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan class=\"\"\u003eYes. Every 5 mg vial comes with a printed and digitally archived COA. The report includes the RP‑HPLC purity reading, retention time, ESI‑MS mass confirmation, and residual solvent profile. The lot number on the vial links directly to that COA.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eCan Tirzepatide be used for human metabolic or therapeutic research?\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan class=\"\"\u003eNo. CorePeptides India supplies Tirzepatide exclusively for in‑vitro laboratory research. It is not manufactured for, nor authorised for, human or veterinary administration, diagnostic procedures, or clinical therapeutic development. All purchase orders are reviewed to uphold this restriction.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Core Supplements","offers":[{"title":"20Mg","offer_id":44198427885627,"sku":null,"price":7999.0,"currency_code":"INR","in_stock":true},{"title":"40Mg","offer_id":44198427918395,"sku":null,"price":8999.0,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0696\/6411\/2699\/files\/ChatGPTImageAug1_2026_12_38_02PM.png?v=1789453670","url":"https:\/\/peptidesinindia.org\/products\/tirzepatide","provider":"Buy Peptides In India","version":"1.0","type":"link"}